Thermo Fisher Scientific Mesothelin Recombinant Mouse Monoclonal Antibody (K1)
Mesothelin을 표적하는 Mouse Recombinant Monoclonal Antibody (Clone K1). 다양한 암세포에서 발현되는 Mesothelin 검출에 적합. WB, IHC, ICC/IF, Flow, ELISA 등 다중 응용 가능. HEK293 발현, Protein A 정제, 1 mg/mL 농도.
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Thermo Fisher Scientific Mesothelin Recombinant Mouse Monoclonal Antibody (K1)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | Assay-dependent |
| Radioimmune Assays (RIA) | Assay-dependent |
| Surface Plasmon Resonance (SPR) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Cynomolgus monkey, Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | K1 |
| Immunogen | The original antibody was generated by immunization of mice with periodate-treated human ovarian carcinoma (OVCAR-3) cells. These mice had previously been made tolerant to normal human kidney membranes. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody can bind the human mesothelium, expressed on many cancer cells such as ovarian carcinoma.
Target Information
Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored, cell-surface glycoprotein predominantly secreted by cells of the mesothelium. It is expressed at restricted levels by normal mesothelial cells of the pleural, pericardial, and peritoneal membranes, but aberrant expression has been documented in various cancers including mesotheliomas, ovarian cystadenocarcinomas, pancreatic adenocarcinomas, endometrioid uterine adenocarcinomas, and squamous cell carcinomas of the esophagus, stomach, lung, and cervix.
Proteolytic cleavage of Mesothelin yields a soluble fragment called megakaryocyte potentiating factor (MPF), which stimulates megakaryocyte colony-forming activity. Both Mesothelin and MPF are implicated in tumorigenesis, promoting proliferation, migration, and metastasis.
Usage Notes
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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