Thermo Fisher Scientific CaV1.2 Monoclonal Antibody (S57)
CaV1.2 단백질을 인식하는 Mouse monoclonal 항체로, WB, IHC, ICC, IP 등 다양한 응용에 사용 가능. Hamster, Human, Mouse, Rabbit, Rat에 반응하며, 단백질 G로 정제된 액상 형태. -20°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | View 1 publication |
| Immunoprecipitation (IP) | 1:200 | - |
| Antibody Microarray (AM) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Rabbit, Rat |
| Published Species | Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S57 |
| Immunogen | Fusion protein amino acids 1507–1733 (intracellular carboxyl terminus) of rabbit Cav1.2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735138 |
Additional Formats
Product Specific Information
1 µg/mL of MA5-27717 was sufficient for detection of Cav1.2 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 240 kDa (varies with cell background due to glycosylation).
Target Information
Gene: CACNA1C
Protein: Voltage-dependent calcium channel, alpha-1C subunit (CaV1.2)
CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. These channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel complex includes alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Multiple isoforms exist due to alternative splicing. The protein binds to and is inhibited by dihydropyridine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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