Thermo Fisher Scientific TRPA1 Polyclonal Antibody
TRPA1 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 시료에 반응. IHC(P), IHC(F), ICC/IF 등 다양한 면역염색에 사용 가능. 항원 친화 크로마토그래피로 정제된 고순도 항체. 장기 보관 시 -20°C에서 안정적 유지.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 7.5 µg/mL | |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from internal region of human TRPA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551634 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon (100%)
Marmoset, Bovine (89%)
Monkey, Elephant, Dog, Rabbit, Pig (84%)
Target Information
TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. TRPA1 is a transformation-associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is also widely expressed outside of the CNS and is dysregulated during oncogenic transformation. The structure of TRPA1 is highly related to ankyrin and transmembrane proteins. Its specific function is not fully determined but may involve signal transduction and growth control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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