Thermo Fisher Scientific TRPM4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 17 amino acid peptide from N-Terminus of human TRPM4. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TRPM4,uniProtId:Q8TD43-1,ncbiNodeId:9606,antigenRange:1,antigenLength:1214,antigenImageFileName:PA5-34283_TRPM4_Q8TD43-1_Rabbit.svg,antigenImageFileNamePDP:PA5-34283_TRPM4_Q8TD43-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2551635

Product Specific Information

Percent identity with other species by BLAST analysis: Human (100%); Chimpanzee, Gorilla, Orangutan, Monkey, Mouse (94%); Gibbon, Galago, Rat, Dog (88%); Marmoset, Elephant, Panda, Bovine, Pig (82%).

Use in IHC with formalin-fixed paraffin-embedded tissues requires proteinase K digestion for antigen retrieval.

Target Information

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+, K+, Cs+, Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.