Thermo Fisher Scientific HDAC4 (internal) Polyclonal Antibody
HDAC4 단백질의 내부 영역(aa 600-650)을 인식하는 Rabbit Polyclonal Antibody. WB, IHC, ELISA, IP 등 다양한 응용 가능. Human, Mouse, Rat, Primate 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태, -20°C 보관.
- 카탈로그번호
- 600-401-J20
- 판매단위
- pk
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Thermo Fisher Scientific HDAC4 (internal) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (IHC) | 1 mg/mL |
| ELISA | 1:20,000–1:60,000 |
| Immunoprecipitation (IP) | 1 mg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the internal region (aa 600–650) of human HDAC4 (UniProt ID: P56524-1). HDAC4 affinity purified antibody prepared from rabbit serum. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 50% glycerol, 0.15M NaCl |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
Stable for several weeks at 4°C as undiluted liquid. Dilute only prior to immediate use.
This antibody is specific towards HDAC4. BLAST analysis suggests cross-reactivity with Human, Mouse, Rat, and Primate based on 100% sequence homology. Cross-reactivity with HDAC4 from other sources has not been determined.
Target Information
Histone deacetylase 4 (HDAC4) deacetylates lysine residues on core histones (H2A, H2B, H3, H4), contributing to epigenetic repression. Plays roles in transcriptional regulation, cell cycle progression, and development.
HDAC4 interacts with MEF2A, MEF2C, and MEF2D, influencing muscle maturation, and participates in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations in HDAC4 are associated with Brachydactyly-mental retardation syndrome (BDMR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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