Thermo Fisher Scientific LSD1 Polyclonal Antibody
LSD1 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot에 적합. Dog, Human, Mouse, Rat 등 다양한 종에 반응. 항원 친화 크로마토그래피로 정제되었으며, PBS 및 젤라틴 완충액에 보존. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Non-human primate, Rat, Zebrafish |
| Published species | Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides corresponding to residues 100–150 of human LSD1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_1070348 |
Product Specific Information
- Suggested positive control: brain lysate, human brain protein.
Target Information
LSD1 is a histone demethylase that specifically demethylates Lys-4 of histone H3, a mark associated with epigenetic transcriptional activation. It functions as a corepressor and contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain.
LSD1 is a component of histone deacetylase complexes and silences genes via demethylation. It oxidizes substrates through FAD to generate imine intermediates that are hydrolyzed.
This enzyme demethylates mono- and tri-methylated Lys-4 of histone H3 and may also act on Lys-9, influencing androgen receptor target gene expression.
Mutations in LSD1 can cause cleft palate, psychomotor retardation, and distinctive facial features.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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