Thermo Fisher Scientific Acid Phosphatase 1 Polyclonal Antibody

Thermo Fisher Scientific Acid Phosphatase 1 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1–3 µg/mL

Product Specifications

Product Specific Information

Suggested positive control: antigen standard for ACP1 (transient overexpression lysate), human liver protein, liver lysate.

Target Information

Low molecular weight protein tyrosine phosphatases, including the human red cell phosphatase HCPTP, are widely expressed cytosolic proteins of approximately 18 kDa that exist in distinct isoforms and are highly selective for phosphotyrosine over phosphoserine or phosphotyrosine.
The HCPTP-A and HCPTP-B proteins expressed in human red cells and placenta are fast and slow forms of red cell acid phosphatase. Like other tyrosine phosphatases, HCPTP is sensitive to inhibition by vanadate and has a catalytic mechanism involving formation of a cystinylphosphate intermediate.
The crystal structure of the bovine heart-derived enzyme BHPTP shows a four-stranded central parallel β-sheet with flanking α-helices and an active site cysteine residue in the typical tyrosine phosphatase sequence context, CXXXXXR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.