Thermo Fisher Scientific DYNC1I2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Bovine and Orangutan

Target Information

Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement.
Cytoplasmic or axonemal Dynein heavy, intermediate, light, and light-intermediate chains are components of minus end-directed motors that transport cellular cargos toward the central region of the cell.
Axonemal Dynein motors contain one to three non-identical heavy chains and cause sliding of microtubules in cilia and flagella, enabling motility.
Cytoplasmic Dynein is a complex of approximately 12 subunits performing essential cellular functions such as organelle transport and centrosome assembly.
The carboxy-terminus of Dynein is important for microtubule-dependent motility and is highly conserved, while the amino-terminal regions are more variable. Several proteins, including Dynactin, LIS1, and nudel (nudE-like), regulate Dynein activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.