Thermo Fisher Scientific BLVRA Polyclonal Antibody
Rabbit polyclonal antibody against human Biliverdin Reductase A (BLVRA). Validated for Western blot and immunoprecipitation. Supplied as liquid, 1 mg/mL concentration. Recommended storage at 4°C. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 75 to 125 of human Biliverdin Reductase A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, which converts heme to iron, carbon monoxide, and biliverdin.
BLVR is unique among all enzymes in being dual pH/dual cofactor-dependent, requiring NADH (pH 6.7) or NADPH (pH 8.7) as an electron donor.
There are two isoforms of BLVR:
- Biliverdin-IX alpha-reductase (BLVRA) — the major component of human adult liver
- Biliverdin-IX beta-reductase (BLVRB) — found predominantly in fetal liver
Bilirubin, the product of BLVR, acts as a biological antioxidant but can also be a neurotoxin and the cause of kernicterus. In addition to its antioxidant role, it inhibits kinase activity and enzymes such as protein kinase C and NADPH oxidase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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