Thermo Fisher Scientific DYNC1I2 Polyclonal Antibody
DYNC1I2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용에 적합합니다. 고순도 항원 친화 크로마토그래피로 정제되었으며, 인간 및 마우스 반응성을 보입니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific DYNC1I2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 588–638 of human Dynein, Cytoplasmic 1, Intermediate Chain 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, and Orangutan
Target Information
Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting ATP’s chemical energy into mechanical movement.
Cytoplasmic and axonemal dyneins consist of heavy, intermediate, light, and light-intermediate chains that function as minus end-directed motors, transporting cellular cargos toward the cell center.
Axonemal dyneins facilitate microtubule sliding within cilia and flagella, enabling motility.
Cytoplasmic dynein is a complex of approximately 12 subunits that performs essential functions such as organelle transport and centrosome assembly.
The carboxy-terminus of dynein is critical for microtubule-dependent motility and is highly conserved, while the amino-terminal regions are variable.
Dynein activity is regulated by proteins such as Dynactin, LIS1, and Nudel (NudE-like).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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