Thermo Fisher Scientific DYNC1I2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, and Orangutan

Target Information

Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement.
Cytoplasmic or axonemal Dynein heavy, intermediate, light, and light-intermediate chains are all components of minus end-directed motors that transport cellular cargos towards the cell center.
Axonemal Dynein motors contain one to three non-identical heavy chains, enabling microtubule sliding in cilia and flagella, essential for motility.
Cytoplasmic Dynein is a ~12-subunit complex (two heavy, two intermediate, four smaller intermediate, and several light chains) performing vital functions such as organelle transport and centrosome assembly.
The carboxy-terminus of Dynein is important for microtubule-dependent motility and is highly conserved, while the amino-terminal regions are more variable.
Regulatory proteins include Dynactin, LIS1, and nudel (nudE-like).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.