Thermo Fisher Scientific SATB2 (Colorectal Carcinoma Marker) Monoclonal Antibody (SATB2/7112)
SATB2 단백질을 인식하는 단클론 항체로, 대장암 등 인체 조직에서의 면역조직화학(IHC) 분석에 적합합니다. 핵 내 발현 단백질 검출에 유용하며, 고순도의 Protein A/G 정제 항체입니다. 연구용으로만 사용 가능합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SATB2/7112 |
| Immunogen | Recombinant fragment (around aa150–350) of human SATB2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human colon or cerebral cortex tissue
- Cellular Location: Nucleus
Target Information
DNA-binding protein SATB2 binds to DNA at nuclear matrix- or scaffold-associated regions and recognizes the sugar-phosphate backbone of double-stranded DNA. It functions as a transcription factor regulating nuclear gene expression by binding to matrix attachment regions (MARs) and inducing chromatin-loop remodeling.
SATB2 acts as a docking site for chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) to promoters and enhancers. It is essential for the initiation of upper-layer neuron (UL1) genetic programs and suppression of deep-layer (DL) and UL2 genes, likely through modulation of BCL11B expression.
Mutations in the SATB2 gene are associated with isolated cleft palate (CPI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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