Thermo Fisher Scientific SATB2 (Colorectal Carcinoma Marker) Monoclonal Antibody (SATB2/7488)
인체 SATB2 단백질을 표적으로 하는 단클론 항체로, 대장암 및 뇌 조직에서 핵 내 발현 검출에 적합합니다. IHC(P)용으로 최적화되어 있으며, 4°C 보관 시 안정적입니다. 단백질 A/G 정제, PBS+BSA 버퍼 포함.
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Thermo Fisher Scientific SATB2 (Colorectal Carcinoma Marker) Monoclonal Antibody (SATB2/7488)
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SATB2/7488 |
| Immunogen | Recombinant fragment (around aa150–350) of human SATB2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human colon or cerebral cortex tissue
- Cellular Location: Nucleus
Target Information
DNA-binding protein SATB2 binds to DNA at nuclear matrix- or scaffold-associated regions and recognizes the sugar-phosphate structure of double-stranded DNA.
SATB2 functions as a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) and inducing local chromatin-loop remodeling.
It acts as a docking site for chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers.
SATB2 is required for initiation of upper-layer neuron-specific genetic programs and for repression of deep-layer neuron genes, likely via modulation of BCL11B expression.
Mutations are associated with cleft palate isolated (CPI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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