Thermo Fisher Scientific SATB2 (Colorectal Carcinoma Marker) Monoclonal Antibody (SATB2/7111)
Human SATB2 단백질을 인식하는 단클론 항체로, 대장암 등에서 핵 내 DNA 결합 단백질 발현 연구에 사용. 파라핀 또는 PFA 고정 조직 IHC에 적합하며, 단백질 A/G로 정제된 액상 형태. 4°C 보관, 동결 금지.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2 µg/mL
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SATB2/7111 |
| Immunogen | Recombinant fragment (around aa150–350) of human SATB2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
DNA-binding protein SATB2 binds to DNA at nuclear matrix- or scaffold-associated regions and recognizes the sugar-phosphate structure of double-stranded DNA.
SATB2 functions as a transcription factor controlling nuclear gene expression through chromatin-loop remodeling at matrix attachment regions (MARs).
It serves as a docking site for chromatin remodeling enzymes, recruiting HDACs or HATs directly to promoters and enhancers.
SATB2 is essential for initiating upper-layer neuron genetic programs and repressing deep-layer neuron genes, likely via modulation of BCL11B expression.
Mutations in SATB2 are associated with isolated cleft palate (CPI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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