Thermo Fisher Scientific SATB2 (Colorectal Carcinoma Marker) Monoclonal Antibody (SATB2/7111)
SATB2 단백질을 표적하는 마우스 단클론 항체로, 대장암 및 신경 발달 연구에 활용 가능. 파라핀 및 PFA 고정 조직에서 IHC에 적합. 고순도 Protein A/G 정제, 보존제 무첨가 PBS 용액 형태. -20°C 보관, 연구용 전용.
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Thermo Fisher Scientific SATB2 (Colorectal Carcinoma Marker) Monoclonal Antibody (SATB2/7111)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SATB2/7111 |
| Immunogen | Recombinant fragment (around aa150–350) of human SATB2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
DNA-binding protein SATB2 binds to DNA at nuclear matrix- or scaffold-associated regions and recognizes the sugar-phosphate structure of double-stranded DNA.
It functions as a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) and inducing local chromatin-loop remodeling.
SATB2 acts as a docking site for chromatin remodeling enzymes, recruiting HDACs (corepressors) or HATs (coactivators) directly to promoters and enhancers.
It plays a critical role in cortical neuron differentiation, repressing Ctip2 and regulating corticocortical connections.
Mutations in SATB2 are associated with cleft palate isolated (CPI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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