Thermo Fisher Scientific Phospho-VAV1 (Tyr174) Polyclonal Antibody
Phospho-VAV1 (Tyr174) 폴리클로날 항체로 인간 및 랫트 시료에서 인산화된 VAV1 단백질을 검출. Western blot과 IHC에 적합하며, 고순도 항원 친화 크로마토그래피로 정제. 연구용으로 안정적인 액상 형태 제공.
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Thermo Fisher Scientific Phospho-VAV1 (Tyr174) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human VAV1 around the phosphorylation site of Tyrosine 174 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553668 |
Product Specific Information
- Detects endogenous VAV1 protein at a molecular weight of approximately 100 kDa.
- Purity >95% by SDS-PAGE.
Target Information
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. It interacts with adenovirus E3-14.7K protein and may utilize TNF-α or Fas-ligand pathways to mediate apoptosis, inflammation, or vasoconstriction. Optineurin may also function in cellular morphogenesis, membrane trafficking, vesicle trafficking, and transcription activation through interactions with RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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