Thermo Fisher Scientific Phospho-Tyrosine Hydroxylase (Ser71) Polyclonal Antibody
Phospho-Tyrosine Hydroxylase (Ser71) 항체로 인간, 마우스, 랫트 시료에서 인산화된 TH 단백질 검출에 사용. Western blot 및 IHC(P) 적용 가능. 항원 친화 크로마토그래피로 정제된 고순도 폴리클로날 항체. 4°C 또는 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human Tyrosine Hydroxylase around the phosphorylation site of Serine 71 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553667 |
Product Specific Information
- Detects endogenous Tyrosine Hydroxylase protein at approximately 58 kDa.
- Purity is greater than 95% by SDS-PAGE.
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters—dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the catalytic domain and activates enzymatic activity.
In humans, four TH mRNA splice variants (hTH1–hTH4) have been identified, differing in their N-terminal regulatory domains but sharing identical catalytic domains. TH catalyzes the conversion of L-tyrosine to L-DOPA and plays a key role in adrenergic neuron physiology.
Alterations in TH function are associated with neurological and cardiovascular disorders such as Parkinson’s disease, schizophrenia, Segawa syndrome, and dystonia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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