Thermo Fisher Scientific CD86 Monoclonal Antibody (BU63), PerCP

Applications

• Flow Cytometry (Flow): 10 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• PE
• PE-Cyanine5
• PE-Cyanine7
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of CD86 (B7-2), a 70 kDa type I transmembrane glycoprotein of the immunoglobulin supergene family. CD86 is expressed on professional antigen-presenting cells such as dendritic cells, macrophages, or activated B lymphocytes.

Target Information

CD86 is one of two ligands (the other being CD80) for CTLA4 and CD28. It acts as a costimulatory molecule in eliciting T-cell help during antigen presentation.

• Antigen presentation without sufficient co-stimulation involving CD86/CD80 can induce tolerance.
• CD86 is a type I membrane protein belonging to the immunoglobulin superfamily.
• It is expressed by antigen-presenting cells and binds to CD28 antigen and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) on T cells.
• Binding with CD28 provides a costimulatory signal for T-cell activation, while binding with CTLA4 negatively regulates T-cell activation, reducing immune response.
• Alternative splicing results in two transcript variants encoding different isoforms of CD86.
• Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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