Thermo Fisher Scientific CD86 Monoclonal Antibody (BU63), PE
Flow Cytometry용 CD86 (BU63) 단클론 항체로, PE 형광체가 결합되어 인간 시료에서 CD86 발현 분석에 적합합니다. B세포, 수지상세포 등 항원제시세포의 표면 CD86 인식. 565/576 nm 파장, 액상 형태, 4°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 20 µL / 1×10⁶ cells |
| Miscellaneous PubMed (Misc) | - |
Publications: View 6 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BU63 |
| Immunogen | B-lymphoblastoid cell line ARH 77 |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156810 |
Additional Conjugate Formats
Product Specific Information
This antibody reacts with an extracellular epitope of CD86 (B7-2), a 70 kDa type I transmembrane glycoprotein of the immunoglobulin superfamily. It is expressed on professional antigen-presenting cells such as dendritic cells, macrophages, and activated B lymphocytes.
Target Information
CD86 is one of two ligands (the other is CD80) for CTLA4 and CD28. It acts as a costimulatory molecule in eliciting T-cell help during antigen presentation. Insufficient co-stimulation involving CD86/CD80 can induce immune tolerance. CD86 is a type I membrane protein expressed by antigen-presenting cells and serves as a ligand for CD28 and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) on T cells. Binding to CD28 provides a costimulatory signal for T-cell activation, while binding to CTLA4 negatively regulates T-cell activation. Alternative splicing results in multiple transcript variants encoding different isoforms. CD86 dysfunction has been associated with gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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