Thermo Fisher Scientific CD86 Monoclonal Antibody (BU63), PE

Applications and Tested Dilution

Publications: View 6 publications

Product Specifications

Additional Conjugate Formats

• Unconjugated
• APC
• FITC
• PE-Cyanine5
• PE-Cyanine7
• PerCP
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of CD86 (B7-2), a 70 kDa type I transmembrane glycoprotein of the immunoglobulin superfamily. It is expressed on professional antigen-presenting cells such as dendritic cells, macrophages, and activated B lymphocytes.

Target Information

CD86 is one of two ligands (the other is CD80) for CTLA4 and CD28. It acts as a costimulatory molecule in eliciting T-cell help during antigen presentation. Insufficient co-stimulation involving CD86/CD80 can induce immune tolerance. CD86 is a type I membrane protein expressed by antigen-presenting cells and serves as a ligand for CD28 and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) on T cells. Binding to CD28 provides a costimulatory signal for T-cell activation, while binding to CTLA4 negatively regulates T-cell activation. Alternative splicing results in multiple transcript variants encoding different isoforms. CD86 dysfunction has been associated with gallbladder squamous cell carcinoma and myocarditis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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