Thermo Fisher Scientific CD86 Monoclonal Antibody (BU63), APC

Applications and Tested Dilution

Publications: View 1 publication

Product Specifications

Additional Formats

• Unconjugated (MA1-10293)
• FITC (MA1-10295)
• PE (MA1-10296)
• PE-Cyanine5 (MA5-38754)
• PE-Cyanine7 (MA5-38755)
• PerCP (MA1-10297)
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with an extracellular epitope of CD86 (B7-2), a 70 kDa type I transmembrane glycoprotein of the immunoglobulin superfamily. CD86 is expressed on professional antigen-presenting cells such as dendritic cells, macrophages, and activated B lymphocytes.

Target Information

CD86 is one of two ligands (the other being CD80) for CTLA4 and CD28. It acts as a costimulatory molecule in eliciting T-cell help during antigen presentation. Insufficient co-stimulation via CD86/CD80 can induce immune tolerance.
CD86 is a type I membrane protein in the immunoglobulin superfamily, expressed by antigen-presenting cells, and serves as a ligand for CD28 and CTLA4 on T cells.
Binding to CD28 provides a costimulatory signal for T-cell activation, while binding to CTLA4 negatively regulates T-cell activation and reduces immune response.
Alternative splicing produces multiple isoforms of CD86. Dysregulation of CD86 has been associated with gallbladder squamous cell carcinoma and myocarditis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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