Thermo Fisher Scientific CD86 Monoclonal Antibody (BU63), APC
인간 CD86 단백질을 인식하는 Mouse IgG1 단클론 항체로, APC 형광체가 결합되어 있습니다. Flow Cytometry에 적합하며, 항원제시세포의 CD86 발현 분석에 유용합니다. 4°C에서 암소 보관하며, 동결 금지.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 10 µL / 1×10⁶ cells |
Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BU63 |
| Immunogen | B-lymphoblastoid cell line ARH 77 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154656 |
Additional Formats
- Unconjugated (MA1-10293)
- FITC (MA1-10295)
- PE (MA1-10296)
- PE-Cyanine5 (MA5-38754)
- PE-Cyanine7 (MA5-38755)
- PerCP (MA1-10297)
- Custom conjugation available upon request
Product Specific Information
This antibody reacts with an extracellular epitope of CD86 (B7-2), a 70 kDa type I transmembrane glycoprotein of the immunoglobulin superfamily. CD86 is expressed on professional antigen-presenting cells such as dendritic cells, macrophages, and activated B lymphocytes.
Target Information
CD86 is one of two ligands (the other being CD80) for CTLA4 and CD28. It acts as a costimulatory molecule in eliciting T-cell help during antigen presentation. Insufficient co-stimulation via CD86/CD80 can induce immune tolerance.
CD86 is a type I membrane protein in the immunoglobulin superfamily, expressed by antigen-presenting cells, and serves as a ligand for CD28 and CTLA4 on T cells.
Binding to CD28 provides a costimulatory signal for T-cell activation, while binding to CTLA4 negatively regulates T-cell activation and reduces immune response.
Alternative splicing produces multiple isoforms of CD86. Dysregulation of CD86 has been associated with gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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