Thermo Fisher Scientific Phospho-AHR (Ser36) Polyclonal Antibody
Phospho-AHR (Ser36) 폴리클로날 항체로 인간, 생쥐, 랫트 시료에서 인산화된 AhR 단백질 검출에 적합. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 고순도 정제, 액상 형태로 안정적 저장 가능.
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Thermo Fisher Scientific Phospho-AHR (Ser36) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human AHR (Accession P35869), corresponding to amino acid residues around phosphorylated Ser36 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816353 |
Product Specific Information
This antibody detects endogenous levels of AhR only when phosphorylated at Serine 36.
Target Information
AHR (Ah Receptor) is part of a protein family including ARNT (HIF-1 Beta) and Drosophila proteins PER and SIM. It contains an N-terminal PAS domain (~200 amino acids) and is expressed in various tissues. AHR binds specific DNA enhancer sequences to initiate transcription of cytochrome P-450 (CYPIA1) mRNA. It acts as a ligand-activated transcription factor regulating biological responses to planar aromatic hydrocarbons.
AHR regulates xenobiotic-metabolizing enzymes such as cytochrome P450. Known ligands include polycyclic and halogenated aromatic compounds (e.g., TCDD). Unlike steroid/thyroid hormone receptors, no physiological ligand is known. In non-ligand activated cells, AHR complexes with HSP90 in the cytoplasm. Upon agonist binding, AHR transforms into a nuclear DNA-binding form, dissociates from HSP90, and forms a heterodimer with Arnt. Diseases associated with AHR include eosinophilic fasciitis and seborrheic dermatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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