Thermo Fisher Scientific Phospho-AHR (Ser36) Polyclonal Antibody
Phospho-AHR (Ser36) 폴리클로날 항체로 인간, 생쥐, 랫트 시료에서 인산화된 AhR 단백질 검출에 적합. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 고순도 정제, 액상 형태로 안정적 저장 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-AHR (Ser36) Polyclonal Antibody
Thermo Fisher Scientific Phospho-AHR (Ser36) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human AHR (Accession P35869), corresponding to amino acid residues around phosphorylated Ser36 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816353 |
Product Specific Information
This antibody detects endogenous levels of AhR only when phosphorylated at Serine 36.
Target Information
AHR (Ah Receptor) is part of a protein family including ARNT (HIF-1 Beta) and Drosophila proteins PER and SIM. It contains an N-terminal PAS domain (~200 amino acids) and is expressed in various tissues. AHR binds specific DNA enhancer sequences to initiate transcription of cytochrome P-450 (CYPIA1) mRNA. It acts as a ligand-activated transcription factor regulating biological responses to planar aromatic hydrocarbons.
AHR regulates xenobiotic-metabolizing enzymes such as cytochrome P450. Known ligands include polycyclic and halogenated aromatic compounds (e.g., TCDD). Unlike steroid/thyroid hormone receptors, no physiological ligand is known. In non-ligand activated cells, AHR complexes with HSP90 in the cytoplasm. Upon agonist binding, AHR transforms into a nuclear DNA-binding form, dissociates from HSP90, and forms a heterodimer with Arnt. Diseases associated with AHR include eosinophilic fasciitis and seborrheic dermatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.