Thermo Fisher Scientific Phospho-BRCA1 (Ser1524) Polyclonal Antibody
BRCA1 단백질의 Ser1524 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며, 인간, 마우스, 랫트 반응성을 가집니다. 고순도 정제 및 안정적 PBS/glycerol buffer로 제공됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BRCA1 (Accession P38398), corresponding to amino acid residues around phosphorylated Ser1524 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816361 |
Product Specific Information
Antibody detects endogenous levels of BRCA1 only when phosphorylated at Serine 1524.
Target Information
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It forms a large multi-subunit complex known as BASC (BRCA1 associated genome surveillance complex), associating with DNA damage sensors and signal transducers. BRCA1 interacts with RNA polymerase II and histone deacetylase complex, contributing to transcription regulation and DNA repair. Mutations in BRCA1 cause a significant proportion of inherited breast and ovarian cancers. Alternative splicing and pseudogene variants have been identified on chromosome 17.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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