Thermo Fisher Scientific Phospho-MEK2 (Thr394) Polyclonal Antibody
인간, 마우스, 랫트에서 인산화된 MEK2(Thr394)를 특이적으로 검출하는 폴리클로날 항체. Western blot, IHC, ICC, IP 등 다양한 응용에 적합. 고순도 정제 및 안정적 PBS/glycerol 저장 포뮬러로 연구용에 최적화.
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Thermo Fisher Scientific Phospho-MEK2 (Thr394) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP2K2 (Accession P36507), corresponding to amino acid residues around phosphorylated Thr394 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816356 |
Product Specific Information
This antibody detects endogenous levels of MEK2 only when phosphorylated at Threonine 394.
Target Information
MAP2K2 (MEK2) is a dual specificity serine/threonine kinase that plays a critical role in mitogen growth factor signal transduction. MEK2 (MAPKK2) activates ERK1/2 and MAPK enzymes by phosphorylating residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop.
MEK1 and MEK2 are activated by dual phosphorylation on serine 218 and 222. Threonine 292 of MEK1 is phosphorylated by ERK2, forming a negative feedback loop that suppresses MEK1 activation.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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