Thermo Fisher Scientific Human SATB1 Synthetic Peptide
인간 SATB1 단백질의 N말단 18개 아미노산 서열에 해당하는 합성 펩타이드로, 항체 PA5-20535의 블로킹 펩타이드로 사용 가능. 인산염 완충액(PBS) 기반 용액 형태이며, 연구용으로만 사용.
- 카탈로그번호
- PEP0655
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human SATB1 Synthetic Peptide
Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the amino terminus of human SATB1.
PEP-0655 can be used as a blocking peptide with polyclonal antibody PA5-20535.
Target Information
SATB1 (DNA-binding protein SATB1) is a crucial silencing factor involved in the initiation of X inactivation mediated by Xist RNA during embryogenesis and in lymphoma. It binds to DNA at AT-rich sequences and matrix- or scaffold-associated regions, recognizing the sugar-phosphate structure of double-stranded DNA.
SATB1 acts as a transcriptional repressor controlling nuclear and viral gene expression in a phosphorylation- and acetylation-dependent manner by binding to matrix attachment regions of DNA and inducing chromatin-loop remodeling.
It modulates genes essential for immune T-cell CD8SP maturation from thymocytes. SATB1-binding sites and Alu-like motifs create a chromatin environment preferentially targeted by HIV-1 integration machinery. HIV-1 Tat may counteract SATB1-mediated repression of IL1 and IL2RA in T-cells by competing for the same domain as HDAC1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.