Thermo Fisher Scientific Human SATB1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the amino terminus of human SATB1.
PEP-0655 can be used as a blocking peptide with polyclonal antibody PA5-20535.

Target Information

SATB1 (DNA-binding protein SATB1) is a crucial silencing factor involved in the initiation of X inactivation mediated by Xist RNA during embryogenesis and in lymphoma. It binds to DNA at AT-rich sequences and matrix- or scaffold-associated regions, recognizing the sugar-phosphate structure of double-stranded DNA.
SATB1 acts as a transcriptional repressor controlling nuclear and viral gene expression in a phosphorylation- and acetylation-dependent manner by binding to matrix attachment regions of DNA and inducing chromatin-loop remodeling.
It modulates genes essential for immune T-cell CD8SP maturation from thymocytes. SATB1-binding sites and Alu-like motifs create a chromatin environment preferentially targeted by HIV-1 integration machinery. HIV-1 Tat may counteract SATB1-mediated repression of IL1 and IL2RA in T-cells by competing for the same domain as HDAC1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.