Thermo Fisher Scientific Human SATB2 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 14 amino acids near the carboxy terminus of human SATB2.
PEP-0653 can be used as a blocking peptide with polyclonal antibody PA5-20533.

Target Information

DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold-associated regions and recognizes the sugar-phosphate structure of double-stranded DNA.
SATB2 functions as a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) and inducing chromatin-loop remodeling.
It acts as a docking site for chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers.
SATB2 is crucial for initiating upper-layer neurons (UL1) specific genetic programs and repressing deep-layer neurons (DL) and UL2 genes, likely through modulation of BCL11B expression.
It serves as a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex.
Mutations in the SATB2 gene are associated with cleft palate isolated (CPI).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.