Thermo Fisher Scientific Human COPS8 Synthetic Peptide
휴먼 COPS8 단백질의 카복시 말단 15 아미노산 서열에 해당하는 합성 펩타이드. PA5-20539 항체의 블로킹 펩타이드로 사용 가능. COP9 시그날로솜 복합체 연구에 적합. 정제된 액상 형태, PBS 버퍼에 0.1% BSA 포함, -20°C 보관.
- 카탈로그번호
- PEP0659
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of human CSN8.
PEP-0659 can be used as a blocking peptide with polyclonal antibody PA5-20539.
Target Information
COPS8 is a COP9 signalosome (CSN), an evolutionarily conserved protein complex of eight subunits that interacts with deubiquitinating enzymes and protein kinases. It is highly homologous to the lid sub-complex of the 26S proteasome.
The CSN complex regulates the ubiquitin conjugation pathway by mediating deneddylation of SCF-type E3 ligase complexes, resulting in decreased ubiquitin ligase activity of SCF complexes such as SCF, CSA, or DDB2.
It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1, and IRF8/ICSBP, possibly via association with CK2 and PKD kinases.
CSN8 encodes the smallest and least conserved but first identified subunit of CSN. Studies show CSN8 is essential for Drosophila development, peripheral T cell homeostasis, and antigen receptor-induced cell cycle entry from quiescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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