Thermo Fisher Scientific Human SATB1 Synthetic Peptide
인간 SATB1 단백질의 C-말단 15개 아미노산 서열에 대응하는 합성 펩타이드입니다. PA5-20534 항체의 블로킹 펩타이드로 사용 가능합니다. 정제된 액상 형태로 제공되며, PBS(pH 7.2) + 0.1% BSA 용액에 보관됩니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PEP0654
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of human SATB1.
PEP-0654 can be used as a blocking peptide with polyclonal antibody PA5-20534.
Target Information
SATB1 (DNA-binding protein SATB1) is a crucial silencing factor that contributes to the initiation of X inactivation mediated by Xist RNA during embryogenesis and in lymphoma.
SATB1 binds to DNA at special AT-rich sequences and nuclear matrix-associated regions, recognizing the sugar-phosphate backbone of double-stranded DNA.
It acts as a transcriptional repressor controlling nuclear and viral gene expression in a phosphorylation- and acetylation-dependent manner by binding to matrix attachment regions and inducing chromatin-loop remodeling.
SATB1 modulates genes essential for maturation of immune T-cell CD8SP from thymocytes.
SATB1-binding sites are preferentially targeted by HIV-1 integration machinery, and HIV-1 Tat may counteract SATB1-mediated repression of IL1 and IL2RA in T-cells by interacting with the same domain as HDAC1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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