Thermo Fisher Scientific Human SATB1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the carboxy terminus of human SATB1.
PEP-0654 can be used as a blocking peptide with polyclonal antibody PA5-20534.

Target Information

SATB1 (DNA-binding protein SATB1) is a crucial silencing factor that contributes to the initiation of X inactivation mediated by Xist RNA during embryogenesis and in lymphoma.
SATB1 binds to DNA at special AT-rich sequences and nuclear matrix-associated regions, recognizing the sugar-phosphate backbone of double-stranded DNA.
It acts as a transcriptional repressor controlling nuclear and viral gene expression in a phosphorylation- and acetylation-dependent manner by binding to matrix attachment regions and inducing chromatin-loop remodeling.
SATB1 modulates genes essential for maturation of immune T-cell CD8SP from thymocytes.
SATB1-binding sites are preferentially targeted by HIV-1 integration machinery, and HIV-1 Tat may counteract SATB1-mediated repression of IL1 and IL2RA in T-cells by interacting with the same domain as HDAC1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.