Thermo Fisher Scientific Fibronectin (Cellular and Plasma) Monoclonal Antibody (TV-1)
Fibronectin 단백질을 인식하는 TV-1 클론의 Mouse Monoclonal Antibody로, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합. Human, Mouse, Pig, Rat 반응성. Protein A/G 정제, PBS 기반 저장. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TV-1 |
| Immunogen | T-cell lymphoma biopsy |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble, cross-linked protein forming high molecular mass polymers. It is abundant during embryonic development and tissue remodeling, and also found as a soluble plasma protein.
Fibronectin consists of repeating modules forming domains that interact with fibronectin itself, other matrix components (e.g., collagen, heparin), and cell receptors (e.g., integrins). It plays key roles in cell adhesion and migration during embryogenesis, wound healing, blood coagulation, host defense, and metastasis.
Fibronectin expression is elevated in non-small cell lung carcinoma, promoting tumorigenicity and resistance to apoptosis induced by chemotherapeutic agents. The gene encoding fibronectin undergoes alternative splicing in three regions, potentially producing up to 20 transcript variants, though some full-length forms remain undetermined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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