Thermo Fisher Scientific Phospho-BCL-2 (Thr69) Polyclonal Antibody
Phospho-BCL-2 (Thr69) 항체로 인산화된 BCL-2 단백질을 특이적으로 검출. Western blot, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도 Rabbit Polyclonal 형식으로 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCL2 (Accession P10415), corresponding to amino acid residues around phosphorylated Thr69 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816257 |
Product Specific Information
This antibody detects endogenous levels of BCL-2 only when phosphorylated at Threonine 69.
Target Information
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. Members of the BCL-2 family can dimerize to modulate apoptosis. For instance, Bag1 forms a heterodimer with BCL-2 to enhance its anti-apoptotic effect, while Bax and Bak promote cytochrome c release from mitochondria to initiate apoptosis. Overexpression or translocation of BCL-2, such as to the Ig heavy chain locus, is implicated in follicular lymphoma and other cancers. Two transcript variants of BCL-2 differ in their C-terminal ends and are associated with human cancers including B-cell lymphoma and prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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