Thermo Fisher Scientific Phospho-BCL-2 (Ser87) Polyclonal Antibody
인간, 마우스, 랫트 시료에서 Ser87 위치에 인산화된 BCL-2를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합하며, 고순도 액상 형태로 제공. 세포 사멸 연구 및 BCL-2 관련 암 연구에 활용 가능.
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Thermo Fisher Scientific Phospho-BCL-2 (Ser87) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCL2 (Accession P10415), corresponding to amino acid residues around phosphorylated Ser87 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816256 |
Product Specific Information
Antibody detects endogenous levels of Bcl-2 only when phosphorylated at Serine 87.
Target Information
BCL-2 is a key regulator of apoptosis that can inhibit or promote cell death. Members of the BCL-2 family interact through dimerization to modulate apoptosis.
Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect.
Bax and Bak promote cytochrome c release from mitochondria, initiating apoptosis.
Constitutive expression of BCL2, such as translocation to the Ig heavy chain locus, is associated with follicular lymphoma.
Most follicular lymphomas express high levels of BCL-2 alpha protein, while normal germinal centers are negative.
Two transcript variants of BCL-2 differ at their C-terminal ends, and overexpression of BCL-2 is linked to cancers such as B-cell lymphoma and prostate cancer.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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