Thermo Fisher Scientific Phospho-JAK2 (Tyr1007, Tyr1008) Recombinant Rabbit Monoclonal Antibody (18H13L8)

Applications

Western Blot (WB)

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• This antibody is predicted to react with Monkey, Rat, Sheep, and Bovine.
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems.
• Expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits.
• Individual clones are screened to select the best candidates for production.
• Advantages include:
  • Better specificity and sensitivity
  • Lot-to-lot consistency
  • Animal origin-free formulations
  • Broader immunoreactivity due to the larger rabbit immune repertoire

Target Information

Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in specific cytokine receptor signaling pathways and is mutated in polycythemia vera.
JAK2 contains the catalytic domain (JH1) and mediates phosphorylation of STAT proteins, which translocate to the nucleus to regulate gene transcription.
JAK2 is essential for IFN gamma-receptor complex initiation, with JAK1 acting as an amplifier.
Mutations in JAK2 are associated with disorders such as Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, Myelofibrosis, and Acute myelogenous leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.