
Thermo Fisher Scientific Phospho-JAK2 (Tyr1007, Tyr1008) Recombinant Rabbit Monoclonal Antibody (18H13L8)
Phospho-JAK2 (Tyr1007, Tyr1008) 인산화 부위를 인식하는 재조합 토끼 단클론 항체로, Western blot에 최적화됨. 높은 특이성과 재현성을 제공하며, 다양한 종에 반응 예측. Protein A 정제, PBS buffer, 4°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 18H13L8 |
| Immunogen | Peptide corresponding to Human JAK2 (aa 1004–1012) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2632976 |
Product Specific Information
- This antibody is predicted to react with Monkey, Rat, Sheep, and Bovine.
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems.
- Expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits.
- Individual clones are screened to select the best candidates for production.
- Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in specific cytokine receptor signaling pathways and is mutated in polycythemia vera.
JAK2 contains the catalytic domain (JH1) and mediates phosphorylation of STAT proteins, which translocate to the nucleus to regulate gene transcription.
JAK2 is essential for IFN gamma-receptor complex initiation, with JAK1 acting as an amplifier.
Mutations in JAK2 are associated with disorders such as Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, Myelofibrosis, and Acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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