Thermo Fisher Scientific TRPM8 Polyclonal Antibody
TRPM8 단백질을 인식하는 sheep polyclonal antibody로, WB 및 IHC에 적합합니다. 합성 펩타이드(aa 500–550)를 면역원으로 사용하였으며, 냉각 감지 관련 TRPM8 채널 연구에 활용됩니다. Lyophilized 형태로 제공되며, 장기 저장 시 -20°C 보관 권장.
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- OST00028W-100UL
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Thermo Fisher Scientific TRPM8 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 500–550 of human TRPM8 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: TRPM8.
Target Information
TRPM8 is a receptor-activated non-selective cation channel involved in the detection of cool sensations by activation below 25°C. It is responsive to icilin, eucalyptol, menthol, and changes in intracellular pH. TRPM8 allows passage of monovalent cations (Na⁺, K⁺, Cs⁺) and divalent cations (Ca²⁺).
Expression is mainly restricted to prostate epithelial cells, with elevated levels observed in prostate cancer. TRPM8 mRNA is also found in certain nonprostatic tumors (breast, colon, lung, skin) but rarely in corresponding normal tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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