Thermo Fisher Scientific TRPV1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitute with 100 µL of distilled water.
• The peptide is homologous in guinea pig.

Target Information

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons.
TRPV1 is a non-selective cation channel related to the TRP family of ion channels such as TRPC3 and TRPC6. It is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 transmembrane domains, a P-loop membrane domain, and 3 ankyrin repeat domains.
TRPV1 is activated by increases in temperature within the noxious range, functioning as a transducer of painful thermal stimuli in vivo. It mediates proton influx and may be involved in intracellular acidosis in nociceptive neurons. Expression is limited to neurons within the sensory ganglia.
Four transcript variants encoding TRPV1 with variations in the 5′ UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.