Thermo Fisher Scientific GRIK1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 0.5–1 µg/mL

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in various normal neurophysiologic processes.
GRIK1 (glutamate receptor 5) belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels.
GRIK1 is expressed in GABAergic interneurons of the hippocampus and participates in the formation of various kainate receptor subtypes with GRIK2 and KA2.
Stimulation of GRIK1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological, and neurodegenerative diseases.
Numerous isoforms of GRIK1 exist and may undergo RNA editing within the second transmembrane domain, altering ion flow properties.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.