Thermo Fisher Scientific SIRT2 Polyclonal Antibody
SIRT2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB 및 ICC/IF에 적합합니다. 인간과 생쥐에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. NIH3T3를 양성 대조로 추천하며, 43 kDa 단백질 검출에 유용합니다.
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Thermo Fisher Scientific SIRT2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminal residues 722–737 of mouse SIR2/SIRT2, with a C-terminal added lysine |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.33 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2301841 |
Product Specific Information
- Recommended positive controls: NIH3T3
- Predicted molecular weight: 43 kDa
Target Information
SIRT2 (Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacetylase (NDAC) involved in gene silencing, cell cycle regulation, and DNA damage repair.
It may act as a tumor suppressor in human gliomas and serve as a molecular marker for these cells.
SIRT2 functions as a redox sensor regulating muscle gene expression in response to food intake and exercise.
During mitosis, SIRT2 is phosphorylated in late G2 phase, throughout M phase, and into cytokinesis.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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