Thermo Fisher Scientific JAB1 Polyclonal Antibody
Thermo Fisher Scientific의 JAB1 Polyclonal Antibody는 Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합합니다. Rabbit IgG 폴리클로날 항체로, 인간, 마우스, 랫트에서 교차 반응이 예상됩니다. 단백질 분해 관련 연구용으로 적합하며, 고순도 액상 형태로 제공됩니다.
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Thermo Fisher Scientific JAB1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
| Immunoprecipitation (IP) | 4–6 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide: SGSGMAQKTWELANNMQ with C-terminal added cysteine, conjugated to KLH, corresponding to amino acids 4–20 of Human JAB1. The corresponding sequence is identical in mouse and rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_794694 |
Product Specific Information
- Recommended positive controls: NIH3T3, PC12, human breast carcinoma
- PA1-25464 is expected to cross react with mouse (100% conserved) and rat (100% conserved) due to sequence homology.
Target Information
JAB-1 is a 38 kDa protein originally described as a coactivator for cJUN. It is present in a large protein complex called the Signalosome, which plays a signaling role in mammalian cells. This complex is analogous to the COP9 complex in plants, important in light-mediated development.
Although the specific function of JAB-1 in this complex is unclear, it has been implicated in targeting proteins for degradation by the proteasome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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