Thermo Fisher Scientific PRMT6 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.25-0.5 µg/mL

-

Immunocytochemistry (ICC/IF)

3-4 µg/mL

-

Immunoprecipitation (IP)

2.5-5 µg/mL

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, conjugated to KLH, corresponding to the N-terminal residues S(2)Q P K K R K L E S G G G G E(16)-C of human PRMT6, with a C-terminal

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.9 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_795227

Product Specific Information

Recommended positive controls: HeLa.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Protein arginine N-methyltransferase 6 (PRMT6) PRMT6 demonstrates type I PRMT activity, capable of forming both omega-N monomethylarginine and asymmetric dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. cts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.