Thermo Fisher Scientific Phospho-Catenin alpha-1 (Ser655, Thr658) Polyclonal Antibody
인산화된 Catenin alpha-1(Ser655, Thr658)을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. WB 및 IHC(P) 실험에 적합하며, 인간·마우스·랫트 반응성. 고순도 정제, 1 mg/mL 농도, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human alpha 1 Catenin around the phosphorylation site of Ser655/Thr658 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899185 |
Product Specific Information
Antibody detects endogenous levels of alpha 1 Catenin only when phosphorylated at Ser655/Thr658.
Target Information
Associates with the cytoplasmic domain of various cadherins. The association of catenins to cadherins forms a complex linked to the actin filament network, essential for cadherins' cell-adhesion properties. Can associate with both E- and N-cadherins. Initially believed to mediate linkage of cadherins to the actin cytoskeleton at adherens junctions, but later found that CTNNA1 does not bind to F-actin when assembled in the complex. The homodimeric form may regulate actin filament assembly and inhibit branching by competing with the Arp2/3 complex. Plays a crucial role in cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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