Thermo Fisher Scientific Phospho-ABL1/ABL2 (Tyr393, Tyr439) Polyclonal Antibody
ABL1/ABL2 단백질의 Tyr393 및 Tyr439 인산화를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot, IHC, ICC/IF에 적합하며, 인간, 마우스, 랫 등 다양한 종에 반응. 1 mg/mL 농도의 액상 시약으로 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ABL1 (Accession P00519), corresponding to amino acid residues around phosphorylated Tyr393 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899183 |
Product Specific Information
This antibody detects endogenous levels of ABL1/2 only when phosphorylated at Tyr393, a site historically referenced as Tyr412.
Target Information
The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl is a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias, including:
- 90–95% of chronic myelocytic leukemia (CML)
- 20–25% of adult acute lymphoblastic leukemia (ALL)
- 2–5% of pediatric ALL
In these leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome, resulting in a chimeric Bcr/c-Abl mRNA encoding an activated Abl protein-tyrosine kinase.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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