Thermo Fisher Scientific Phospho-alpha Actinin 1/2/3/4 (Ser159) Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of ACTN1/2/3/4 only when phosphorylated at Ser159.

Target Information

Alpha actinins belong to the spectrin gene superfamily, representing a diverse group of cytoskeletal proteins including alpha and beta spectrins and dystrophins.
Alpha actinin is an actin-binding protein with multiple roles in different cell types:

• In nonmuscle cells, it is found along microfilament bundles and adherens-type junctions, binding actin to the membrane.
• In skeletal, cardiac, and smooth muscle cells, it localizes to the Z-disc and dense bodies, anchoring myofibrillar actin filaments.
  This gene encodes a nonmuscle, cytoskeletal alpha actinin isoform and maps to the same site as the erythroid beta spectrin gene.
  Three transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지: PA5-114548_alpha_Actinin_1234_O43707-1_Rabbit.svg)
(이미지: PA5-114548_alpha_Actinin_1234_Q08043-1_Rabbit.svg)