Thermo Fisher Scientific CRALBP Polyclonal Antibody, FITC
CRALBP 단백질을 인식하는 FITC 결합 토끼 다클론 항체로, Western blot, ELISA, IP에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며 형광 검출이 가능합니다. 시료는 액상 형태로 제공되며 -20°C에서 암소 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 260–317 of human Retinaldehyde-binding protein 1 (CRALBP/RLBP1) |
| Conjugate | FITC (Fluorescein isothiocyanate) |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cellular retinaldehyde-binding protein (CRALBP) plays a crucial role in the regeneration of 11-cis-retinal used in rod visual pigments such as opsin and rhodopsin. After photoisomerization to all-trans-retinal, it is converted to all-trans-retinol, which diffuses into the retinal pigment epithelium (RPE) for reconversion to 11-cis-retinol and oxidation to 11-cis-retinal, processes mediated by CRALBP. Mutations in CRALBP are associated with visual disorders including Bothnia dystrophy, retinitis punctata albescens, retinitis pigmentosa, and Newfoundland rod-cone dystrophy. CRALBP serves as a marker for RPE and Müller glial cells in the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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