Thermo Fisher Scientific CRALBP Polyclonal Antibody, Biotin
CRALBP 단백질을 표적으로 하는 Thermo Fisher의 Biotin 결합 Rabbit Polyclonal 항체. Western blot, ELISA, IP 등 다양한 응용 가능. 고순도 Affinity chromatography 정제 제품으로 시각 관련 연구에 적합. 인체, 마우스, 랫트 반응성 확인.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 260–317 of human Retinaldehyde-binding protein 1 (CRALBP / RLBP1) |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cellular retinaldehyde-binding protein (CRALBP) plays a crucial role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin. After photoisomerization, 11-cis-retinal is converted to all-trans-retinal and subsequently to all-trans-retinol, which diffuses into the retinal pigment epithelium (RPE) for conversion back to 11-cis-retinol and oxidation into 11-cis-retinal, processes mediated by CRALBP.
Mutations in CRALBP are associated with visual disorders including Bothnia dystrophy, retinitis punctata albescens, retinitis pigmentosa, and Newfoundland rod-cone dystrophy.
CRALBP expression serves as a marker for RPE and Müller glial cells in the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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