Thermo Fisher Scientific Phospho-Tau (Thr231) Polyclonal Antibody
Tau 단백질의 Thr231 인산화 부위를 특이적으로 인식하는 폴리클로날 항체로, 인간 및 생쥐 시료에 반응합니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- 44746G
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-Tau (Thr231) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 8 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:200 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1 µg/mL | View 2 publications |
| ELISA | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Rat, Tag |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from the region of human Tau containing threonine 231. The sequence is conserved in mouse and rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533742 |
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between them.
Axonal polarity is determined by Tau (MAPT) localization. Short isoforms provide cytoskeletal plasticity, while longer isoforms contribute to stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease (AD) brains.
Hyper-phosphorylation impairs Tau’s microtubule binding, leading to destabilization and neuronal degeneration in AD. Tau is phosphorylated by kinases such as GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also found in neurofibrillary lesions associated with other CNS disorders including Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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