Thermo Fisher Scientific Phospho-Tau (Thr205) Polyclonal Antibody
Tau 단백질의 Thr205 위치 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 Immunohistochemistry에 적합하며, 항원 친화 크로마토그래피로 정제됨. Alzheimer’s disease 연구 등 신경퇴행성 질환 관련 연구용으로 사용 가능.
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Thermo Fisher Scientific Phospho-Tau (Thr205) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | 28 publications |
| Immunohistochemistry (IHC) | Assay-dependent | 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | - | 1 publication |
| Immunohistochemistry - Free Floating (IHC (Free)) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL | 5 publications |
| ELISA | - | 1 publication |
| Dot blot (DB) | - | 1 publication |
| Miscellaneous PubMed | - | 1 publication |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Cat, Chicken, Dog, Human, Mouse, Rat, Tag |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from the region of human Tau containing threonine 205 (sequence conserved in mouse and rat) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533738 |
Product Specific Information
Purified from rabbit serum by sequential epitope-specific chromatography. The antibody has been negatively preadsorbed using a non-phosphopeptide to remove reactivity with non-phosphorylated Tau. The final product is affinity purified using a Tau-derived peptide phosphorylated at threonine 205.
This antibody has been used in western blotting and immunohistochemistry. In western analysis, recombinant human Tau treated with GSK3β was used as a positive control.
Each vial contains sufficient material for approximately 10 mini-blots.
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds plasma membrane components, functioning as a linker protein.
Hyper-phosphorylated Tau forms paired helical filaments (PHF), the major component of neurofibrillary tangles in Alzheimer’s disease. Phosphorylation impairs microtubule binding, leading to neuronal degeneration.
Tau phosphorylation is mediated by multiple kinases, including GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is implicated in Alzheimer’s, Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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