Thermo Fisher Scientific MECT1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot and refreeze at -20°C or below for long-term storage.
• Avoid repeated freeze/thaw cycles.
• Centrifuge if not clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

This affinity-purified antibody is directed against human MECT1 protein. BLAST analysis suggests cross-reactivity with MECT1 from human, mouse, rat, zebrafish, pufferfish, and bovine based on 100% homology with the immunizing sequence. Reactivity with homologues from other sources is not known.

Target Information

MECT1 acts as a transcriptional coactivator for CREB1, activating transcription through both consensus and variant cAMP response element (CRE) sites. It functions in the SIK/TORC signaling pathway, active when dephosphorylated, and enhances CREB1-TAF4 interaction. It regulates CREB-activated genes such as StAR, coactivates PGC1α, and induces mitochondrial biogenesis in muscle cells. In the hippocampus, it is involved in late-phase long-term potentiation (L-LTP) maintenance and dendritic growth of cortical neurons. Together with SIK1, it regulates light-induced circadian clock entrainment by coactivating CREB-mediated transcription of PER1.
[Source: UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.