Thermo Fisher Scientific MECT1 Polyclonal Antibody
Rabbit polyclonal antibody against human MECT1 protein. Validated for WB and ELISA. Cross-reactive with human, mouse, rat, zebrafish, fish, and bovine. Supplied as liquid, 1 mg/mL, affinity-purified, stored at -20°C. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:10,000–1:40,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Fish, Human, Mouse, Rat, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Affinity-purified antibody prepared from whole rabbit serum immunized with a synthetic peptide corresponding to amino acids 19–34 of human MECT1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02 M potassium phosphate, pH 7.2, with 0.15 M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot and refreeze at -20°C or below for long-term storage.
- Avoid repeated freeze/thaw cycles.
- Centrifuge if not clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
This affinity-purified antibody is directed against human MECT1 protein. BLAST analysis suggests cross-reactivity with MECT1 from human, mouse, rat, zebrafish, pufferfish, and bovine based on 100% homology with the immunizing sequence. Reactivity with homologues from other sources is not known.
Target Information
MECT1 acts as a transcriptional coactivator for CREB1, activating transcription through both consensus and variant cAMP response element (CRE) sites. It functions in the SIK/TORC signaling pathway, active when dephosphorylated, and enhances CREB1-TAF4 interaction. It regulates CREB-activated genes such as StAR, coactivates PGC1α, and induces mitochondrial biogenesis in muscle cells. In the hippocampus, it is involved in late-phase long-term potentiation (L-LTP) maintenance and dendritic growth of cortical neurons. Together with SIK1, it regulates light-induced circadian clock entrainment by coactivating CREB-mediated transcription of PER1.
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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