Thermo Fisher Scientific ALX4 Monoclonal Antibody (OTI6B3), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The ALX4 gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue.
Mutations in this gene cause Parietal Foramina 2 (PFM2), an autosomal dominant disorder associated with deficient ossification of parietal bones.
Other mutations can lead to frontonasal dysplasia with alopecia and hypogonadism, implicating ALX4 in craniofacial development and hair follicle formation.
Deletion of chromosome 11 segment containing this gene, del(11)(p11p12), results in Potocki-Shaffer syndrome (PSS), characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males.
In mouse, this gene utilizes dual translation initiation sites located 16 codons apart.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.

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