Thermo Fisher Scientific PR3 Monoclonal Antibody (WGM2), FITC
인간 PR3 단백질을 인식하는 WGM2 클론의 마우스 단클론 항체로, FITC 형광 표지됨. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합. PR3 활성 억제 및 PR3-ANCA 결합 부분 억제 기능 보유. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 1:50 |
| Immunoprecipitation (IP) | 1:50 |
| Functional Assay (Functional) | 1:50 |
| Inhibition Assays (IA) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | WGM2 |
| Immunogen | Monoclonal antibody WGM2 reacts with human proteinase 3 (PR3), a 30 kDa protein. |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_3093254 |
Additional Formats
Product Specific Information
Monoclonal antibody WGM2 blocks PR3 activity and partially inhibits the binding of human PR3-ANCA to PR3.
Target Information
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, it enhances endothelial cell barrier function and vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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