Thermo Fisher Scientific PR3 Monoclonal Antibody (WGM2)
인간 PR3 단백질을 인식하는 WGM2 클론의 Mouse IgG1 단일클론 항체입니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 사용 가능합니다. PR3 활성 억제 및 PR3-ANCA 결합 억제 기능을 보유하며, 4°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 1:50 |
| Immunoprecipitation (IP) | 1:50 |
| Functional Assay | 1:50 |
| Inhibition Assay (IA) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | WGM2 |
| Immunogen | Monoclonal antibody WGM2 reacts with human proteinase 3 (PR3). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.1% BSA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_3091064 |
Available Formats
- FITC conjugate: MA5-49095
- Custom conjugation available: Request here
Product Specific Information
Monoclonal antibody WGM2 blocks PR3 activity and partially inhibits the binding of human PR3-ANCA to PR3.
Target Information
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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