Thermo Fisher Scientific PTX3 Monoclonal Antibody (MNB1)
인간 PTX3 단백질을 인식하는 Rat IgG2b 단일클론 항체로, Western blot, Flow cytometry, Functional 및 Inhibition assay에 사용 가능. 비결합형 액상 형태이며 Protein G로 정제됨. PBS + 0.1% BSA 용액에 보관하며 4°C에서 안정적. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50 |
| Flow Cytometry (Flow) | 1:50 |
| Functional Assay | 1:50 |
| Inhibition Assay (IA) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MNB1 |
| Immunogen | Human recombinant PTX3 (target family: PTX3, UniProt ID: P26022-1, antigen range: 1–381) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.1% BSA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_3091072 |
Target Information
Pentraxins are a protein superfamily characterized by a cyclic multimeric structure. PTX3, also known as tumor necrosis factor-stimulated gene sequence-14 (TSG14), is a secreted pattern-recognition receptor with a non-redundant role in resistance to selected microbial agents. PTX3 belongs to the "long pentraxins" family, which have C-terminal pentraxin domains and novel N-terminal domains.
PTX3 binds selected pathogens including Aspergillus fumigatus, Pseudomonas aeruginosa, and Salmonella typhimurium. It is synthesized in IgA glomerulonephritis and activates mesangial cells. Secretion of PTX3 in adipose cells can be induced by TNF. PTX3 is involved in amplification of inflammatory reactions and regulation of innate immunity. The human PTX3 gene maps to chromosome 3q25.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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