Thermo Fisher Scientific CD157 Monoclonal Antibody (eBioSY11B5 (SY11B5)), PE-Cyanine7, eBioscience

Thermo Fisher Scientific CD157 Monoclonal Antibody (eBioSY11B5 (SY11B5)), PE-Cyanine7

Applications and Tested Dilution

• Flow Cytometry (Flow): 5 µL (0.125 µg)/test
• Publications: View 1 publication

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 488
• APC
• NovaFluor Blue 660-120S
• NovaFluor Red 710
• NovaFluor Yellow 590
• NovaFluor Yellow 610
• PE
• Super Bright 436
• Super Bright 600
• Request custom conjugation

Product Specific Information

The eBioSY11B5 monoclonal antibody recognizes human CD157 (Mo5, BST-1).
CD157 is a 42–45 kDa GPI-anchored protein with structural and functional similarities to CD38.
It is expressed on monocytes and macrophages and identical to BST-1, initially found in bone marrow stromal cells stimulating pre-B cell proliferation.
CD157 functions as both enzyme and receptor, involved in NAD⁺ metabolism and intracellular Ca²⁺ regulation.
Upon ligand binding, CD157 initiates signal transduction leading to phosphorylation of cytoplasmic proteins such as FAK.

Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated for flow cytometric analysis of normal human peripheral blood cells.
Use at 5 µL (0.125 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test).

Light Sensitivity: Protect from light due to photo-induced oxidation.
Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-8222-49) or 1-step Fix/Lyse Solution (Product # 00-5333-54) for up to 3 days at 4°C in the dark.
Excitation: 488–561 nm; Emission: 775 nm; Laser: Blue, Green, Yellow-Green.
Filtration: 0.2 µm post-manufacturing filtered.

Target Information

Bone marrow stromal cell antigen 1 (BST1) is a GPI-anchored molecule facilitating pre-B cell growth.
Also known as ADP-ribosyl cyclase 2 and DAMP-1, BST1 is expressed by the BST1 gene in humans.
Its expression increases in bone marrow stromal cells from rheumatoid arthritis patients, potentially contributing to polyclonal B cell abnormalities via overexpression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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